High Levels Of Type Of Cholesterol Not Routinely Screened Linked To Heart Attacks

A genetic analysis from three studies of people living in Denmark found that those who had higher levels of a cholesterol known as lipoprotein (a) due to genetic reasons were at higher risk of heart attack. The researchers suggested that although their findings were strong enough to support the idea that higher levels of lipoprotein (a) due to genetic reasons very probably cause higher risk of heart attack, only randomized clinical trials that show fewer heart attacks occur when lipoprotein (a) is reduced through therapy can prove it.

The study was the work of Dr Pia R Kamstrup, of Herlev Hospital, Copenhagen University Hospital in Herlev, Denmark, and colleagues, and is published in the 10 June issue of the Journal of the American Medical Association, JAMA.

Despite the fact that statins are now routinely used to lower levels of low-density lipoprotein (LDL, or “bad” cholesterol), myocardial infarction (MI or heart attack) remains a leading cause of illness and death, wrote the authors.

There is a need to identify other risk factors as targets for treatment they said. Lipoprotein (a), a cholesterol that is not included in routine cholesterol screening, has been suggested as a potential candidate, but there is not enough evidence of how closely it is linked to heart attack risk. Read more